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AN EXPERIMENTAL STUDY ON THE EFFECTS OF Co-60 IRRADIATION ON THE RAT TONGUE TISSUE

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Abstract

ÀúÀÚ´Â ¹æ»ç¼± Á¶»ç°¡ ¸ÀÀÇ ÀÎÁö¿Í ÀúÀ۽ÿ¡ ¸Å¿ì Áß¿äÇÑ ¿ªÇÒÀ» ÇÏ´Â ¼³Á¶Á÷¿¡ ¹ÌÄ¡´Â
¿µÇâÀ» °üÂûÇϱâ À§ÇÏ¿©, Co-60½ÉºÎ Ä¡·áÀåÄ¡(Model 4M60, Picker Co.)¸¦ ÀÌ¿ëÇÏ¿©, ¹é¼­
µÎ°æºÎ¿¡ 8, 13, 180GrayÀÇ °¨¸¶¼±À» Á¶»ç, ½ÇÇèÇÑ ÈÄ, 1, 3, 6, 12½Ã°£, 1, 3ÀÏ, 1, 2, 4ÁÖ¿¡
Èñ»ý½ÃÄÑ ±¤ÇÐ Çö¹Ì°æÀ¸·Î °üÂûÇÑ ¹Ù, ¾Æ·¡¿Í °°Àº °á°ú¸¦ ¾ò¾ú´Ù.
1. ¹æ»ç¼± Á¶»ç¿¡ ÀÇÇØ ¼³ÀÇ ±ÙÁ¶Á÷Àº Á¶»çÈÄ 1½Ã°£¿¡ ½ÉÇÏ°Ô ºÎÁ¾µÇ¾úÀ¸³ª, ½Ã°£ÀÌ °æ°ú
µÊ¿¡ µû¶ó Á¡Â÷ ȸº¹µÇ¾ú´Ù.
2. ¹æ»ç¼± Á¶»ç¿¡ ÀÇÇØ ¼³ÀÇ »óÇÇÁ¶Á÷Àº Ãʱ⿡ ±âÀú¼¼Æ÷°¡ Áõ½ÄµÇ¾úÀ¸³ª Á¡Â÷ ¼Ò½ÇµÇ¾ú
°í, °¢È­ÁõÀº Á¡Â÷ Áõ°¡µÇ¾ú´Ù.
3. ¹æ»ç¼± Á¶»ç¿¡ ÀÇÇØ ¼³³» ±ÙÀº Ãʱ⿡ ½ÉÇÏ°Ô À§Ãà º¯¼ºµÇ¾úÀ¸³ª Á¡Â÷ ȸº¹µÇ¾î ÀçÇü
¼ºµÇ¾ú´Ù.
4. ¹æ»ç¼± Á¶»ç¿¡ ÀÇÇÑ Á¶Á÷ÀÇ º¯È­´Â ¹æ»ç¼± Á¶»ç¼±·®ÀÇ Áõ°¡¿¡ µû¶ó ½ÉÇÏ°Ô ³ªÅ¸³µ´Ù.
#ÃÊ·Ï#
It is known that radiation therapy is a kind of treatment choices of the maxillofacial
tumors. This study is designed to investigate the effects of irradiation on rat's tongue
tissues as functional tissues which relate to taste, mastication, and pronunciation. 88 rats
(Sprague Dawley branch, male) were divided into control group of 4 and experimental
group of 84. Experimental group was singly exposed to Co-60 irradiation with 8, 13, 18
Gy in the head and neck region.
Animals were sacrificed on 1 hour, 3 hours, 6 hours, 1 day, 3 days, 7 days, and 28
days after the irradiation. The specimens were observed by histopathological examination
employing H-E stain and Van-Gieson stain.
The results were follows;
1. The tongue tissue were severely swollen on the 1 hour after irradiation, but
gradually decreased in course of time.
2. The basal cells of epithelium of tongue proliferated at initial stage of irradiation,
but gradually decreased. The Keratin layer were gradually increased.
3. The muscles within the tongue were severely degenerated at initial stage of
irradiation, but gradually recovered almost normally.
4. The tissue changes after irradiation were gradually increased by the degree of
irradiation.

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